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Therefore, considering the overlapping yet distinct roles of insulin and IGF-1 in the brain, disruptions in their signaling pathways due to IR may contribute to the neurobiological mechanisms underlying depression in individuals with T2DM

Damar Cakirca, T., Ceylan, M

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Additionally, ME/CFS patients were found to have similar humoral and cellular immune responses as healthy controls post-influenza vaccination (170) without worsening ME/CFS symptoms or causing adverse effects (164, 171)