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It could take years for us to fully grasp the impact of GLP-1s expanded usageespecially as ongoing research finds new applications for conditions like cardiovascular disease, sleep apnea, and liver disease

H.MeruvuS.SonkarR.et al (2020)

Jul 4 2023;12(13):e029852

More results from the ACHIEVE Phase 3 clinical trial program will be shared later this year, along with findings from the ATTAIN Phase 3 clinical trial program evaluating orforglipron for weight management

for example glucose induces the release of GLP-1 from human duodenum and ileum via electrogenic transporters (SGLT1) and voltage-gated Calcium and Sodium channels responsible for the membrane depolarization and hormonal release (53, 72)

Chemie , Band 49, 1906, S