A blood test is essential to confirm vitamin B12 deficiency and highlight the importance of early detection and treatment
The 2025 update expands on this and underscores the value of antibody-based screening for presymptomatic T1DM in individuals with a family history of the disease

Kardie Tobb, DO, MS, FASPC, FACC, a boardcertified preventive cardiologist and the medical director for the Cone Health HeartCare Women's Heart Health and Cardio-Obstetrics Clinic, explains some of the most common reasons why GLP-1s may not deliver the results you're hoping for, including: You need a higher dose and have not yet reached a therapeutic dose as determined by your doctor High intake of liquid calories , including alcohol and ultra-processed foods Not getting enough protein , which can leave you persistently hungry and makes it harder to feel full Advanced diabetes or insulin resistance Taking other medications such as sulfonylureas, which lower blood sugar but can lead to weight gain Not adhering to your dosing schedule , such as inconsistent weekly injections or missed doses Differences in gut hormones or genetics And just because your GLP-1 isn't working immediately doesn't mean it won't work for you
Gently insert the suppository into the anus, narrow end first
Weight gain on semaglutide is uncommon but possible, typically occurring during dose escalation phases, after stopping the medication, or due to compensatory eating patterns
Your skin will be red, potentially swollen, and youll see visible peeling