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Until recently, fascia was largely ignored in knee OA research, but new discoveries in the 2020s show that fascial structures play critical roles in knee pain, stiffness, biomechanics, and knee OA progression

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Treatment with Fer-1, Lip-1, or neural stem cell-derived extracellular vesicles enriched in CDC42 substantially attenuates cerebrovascular damage and cognitive deficits in PD mice (Li et al., 2025b)