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However, ferroptosis inducers cannot promote ferroptosis in all cancer cell lines, indicating that the genetic and metabolic susceptibility determinants limit the application of ferroptosis inducers in vivo

During this process, the mitochondrial matrix reductase ferredoxin 1 (FDX1) functions as a critical upstream regulator by reducing Cu 2 + to the more toxic Cu + species and by promoting LIAS-mediated protein lipoylation

doi: 10.1016/j.immuni.2019.03.009 96 MarquesLNegre-SalvayreACostaLCanonne-HergauxF

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