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People with this chronic, progressive neurological disorder have high levels of oxidative stress and premature cellular die off in a part of the brain called the substantia nigra

Some people are interested in using very low doses of GLP-1 medications (like semaglutide or tirzepatide) for potential benefits beyond weight loss such as reducing inflammation, improving metabolic health, or supporting longevity

A lot of these issues could potentially be avoided with an oral option. Pills Wont Suit Every Patient Still, not everyone will find orforglipron patient friendly because you need to take it every day

The 11-12% average weight loss at the highest dose could be exactly what they need, without the intensity of a dual-receptor agonist

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doi: 10.1016/j.ajem.2019.158426 [PubMed] 31980292 Thomas C, Priano J, Smith TL