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Guideline 3: High-Dose B12 for Severe Neuropathy High-dose B12 therapy is a promising treatment for severe neuropathy

Beta-3 adrenergic receptor expression begins increasing in adipose tissue, and the baseline rate of lipolysis elevates

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insulin resistance dampens the signal

It plays a crucial role in maintaining the health of the nervous system and in the production of genetic material (DNA and RNA)

There is theoretical concern about effects on cell proliferation, including potential influence on abnormal cell growth