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A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer

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Therefore, TAG hydrolysis appears independent of NHR-49, which is further supported by the unaltered expression of critical lipolysis regulators, hormone sensitive lipase, hosl-1 , and the adipose triglyceride lipase, atgl-1 , in nhr-49(nr2041) mutant animals (Supplementary Fig