Your Nervous System Is Stuck in High Alert Mode Long-term stress keeps cortisol and adrenaline elevated, which disrupts sleep quality, gut function, and cellular repair
If the goal is skin-specific benefit with an evidence base you can actually check, topical is not the compromise option it's often framed as
It improves insulin sensitivity by regulating Akt pathway and hyperphosphorylation of IRS-1, decrease MDA levels, elevates SOD, and CAT levels, and the GSH/oxidized glutathione ratio, and activates Nrf2 signalling in chronic high fat/high sucrose (HFHS) diet-fed mice (Zhang et al., 2020)
Cellular Antioxidant Support Glutathione, combined with vitamin C, contributes to the protection of cells from oxidative stress
Glutathione (GSH), also known as -L-glutamyl-L-cysteinyl-glycine, is required in the maintenance and regulation of the thiol-redox status [16]
Prognostic relevance of cardiac troponin T levels and their dynamic changes measured with a high-sensitivity assay in acute ischaemic stroke: analyses from the TRELAS cohort