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Many patients receive B12 support to help with overall energy as their eating patterns shift during the program
Intramuscular glucagon is used by family members of patients with type 1 diabetes, but glucagon is less useful in type 2 diabetes because it stimulates insulin secretion as well as glycogenolysis
Fewer reconstitution events per protocol cycle
Unlike small-molecule drugs, peptides are susceptible to degradation through hydrolysis, oxidation, and aggregation processes that can render the compound inactive or, in some cases, produce harmful breakdown products
The most successful treatments currently available include glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), exemplified by semaglutide (approved in 2017, $19.9 billion sales in 2023) 3 and tirzepatide (approved in 2022, $5.3 billion sales in 2023) 4
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