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(24) demonstrated that exogenous stimuli activate Toll-like receptors (TLRs) and the downstream nuclear factor-B (NF-B) pathway, which upregulates NLRP3 expression

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Oxidative stress is essentially the damage that is done to the body when the amount of free radicals is higher than the number of antioxidants being produced by the body

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PNS treatment restores renal function via attenuating the accumulation of injury mitochondria and cell apoptosis in TECs (Liang et al., 2017