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Invest Ophthalmol Vis Sci 46:431119, PMID: 16249513 Robillard JM, Gordon GR, Choi HB, Christie BR, MacVicar BA (2011) Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult

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The human CTR was modified to contain an N-terminal Flag tag epitope and a C-terminal 8 histidine tag epitope, each flanked by a HRV 3 C protease cleavage sites

Along with its known function combating oxidative stress, GSH is also important for the detoxification of xenobiotics and metabolites, the regulation of cell growth and cell death, the regulation of the nitric oxide cycle, the storage of cysteine, the maintenance of redox potential and the modulation of immune function

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As of 2024, IgG Fc engineering as a strategy to prolong plasma half-life is used in approved therapeutics for diverse pathologies, including for instance neutralization of a virus (YTE containing