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Topical Administration (Most Common) The most widely used approach is topical application via DMSO (dimethyl sulfoxide): Dissolve 3-5mg Dihexa in a few drops of DMSO Apply to forearm skin (DMSO acts as a carrier to drive the peptide through the skin) DMSO concentration: ~20-30% in the solution Pros: Effective absorption, avoids injection Cons: DMSO has a strong garlic-like odor that can transfer to breath/skin Starting Dose Begin at 1-3mg topically to assess response Work up to 3-5mg if tolerating well Cycling Protocol Dihexa appears to have lasting effects that persist after stopping likely due to synaptogenesis (new connections don't disappear when you stop)
Probucol also has anti-inflammatory, antioxidant and neuroprotective properties
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Gou LY, Li AN, Yang JJ, Zhang XC, Su J, Yan HH, et al
NICE-appraised licensed alternatives such as semaglutide (Wegovy) and liraglutide (Saxenda) are available through regulated UK weight management services
The real magic unfolds over 4-8 weeks of treatment, with benefits lasting months to a year
