PMID 27109090
Protein : Adequate protein intake (0.8-1.0 g/kg body weight daily, or higher for older adults) supports both muscle and bone health during weight loss
However, further research is needed to confirm that the improvements in systemic inflammation and joint symptoms observed with these therapies are also tied to improvements in joint inflammation.
With so many options out there, finding what works best for you requires some careful thinking about both effectiveness and safety

ALA may be helpful for: People with diabetic neuropathy: ALA has the strongest clinical evidence for reducing nerve pain and improving quality of life in this group.1 Those with type 2 diabetes or metabolic syndrome: Modest improvements in insulin sensitivity and blood sugar markers have been observed in some studies.24 People with high oxidative stress: Research shows that ALA can help lower oxidative stress markers like CRP in individuals with chronic inflammation or metabolic risk factors.27 Those with nerve-related conditions or mitochondrial dysfunction: Early research suggests ALA may help support nerve health in contexts like multiple sclerosis.3 However, ALA may not be appropriate if: Youre generally healthy and eat a balanced diet Your body naturally produces some ALA, and small amounts are found in foods like spinach, broccoli, red meat, and organ meats.41 In healthy individuals, taking an ALA supplement may offer little to no added benefit

Unfortunately, the study was unsuccessful, and the trial was halted early