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using escalating dosing, as follows: 0.01 mg/kg semaglutide twice weekly for week one, 0.03 mg/kg semaglutide twice weekly for week two and 0.05 mg/kg semaglutide twice weekly for week three (as shown in Fig

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These effects typically peak during dose titration and improve over time but cause 20-50 percent of patients to discontinue treatment within the first year

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When comparing semaglutide to liraglutide, studies have shown that both medications can cause an increase in heart rate

Patients using both are finding a neutralizing effect