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EMP inhibitors carry on-target toxicities for normal tissues dependent on glycolytic metabolism (e.g., brain, retina, and testes), necessitating tumor-selective therapeutic strategies

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Approved indications include adults with BMI of 30 or greater (obesity), or BMI of 27 or greater with at least one weight-related health condition

Allowing the pen to warm to room temperature for 15 to 20 minutes before use reduces these issues significantly

Genetic loci influencing kidney function and chronic kidney disease

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