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These treatments need to be used with caution, however, as abrupt cessation of GLP-1 receptor agonists can lead to rapid weight gain in a patient who has not yet modified their lifestyle

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To validate the observed closed conformation and to study their effects on receptor activation, we engineered disulfide bonds on the wild-type GLP-1R to lock the interactions between the ECD and ECL1/3

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It slows how fast your stomach empties, regulates insulin, lowers blood sugar, and sends a message to your brain that youre done eating

J Investig Med