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The L-Arginine paradox is a well-documented scientific puzzle: In published studies at researched doses, L-Arginine supplementation has sometimes been shown to improve blood flow and lower blood pressure even though normal plasma L-Arginine levels already exceed the concentration the eNOS enzyme needs to produce nitric oxide - a finding that researchers describe as the "L-Arginine paradox." You'd expect extra L-Arginine to have no effect - but it often does

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some of the study period preceded the approval of semaglutide and tirzepatide to treat obesity