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5.4 Mitochondrial dysfunction as an upstream driver of amyloid and tau pathology A significant shift in Alzheimer's disease (AD) research is represented by the Mitochondrial Cascade Hypothesis, which posits that mitochondrial dysfunction is the primary driver of AD pathophysiology, rather than a secondary consequence of Tau or A accumulation (94)

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Clinical Trials: Impact of B12 Supplementation on Metabolites Serum B12 Holotranscobalamin Methylmalonic Acid Homocysteine Notes on Clinical Trials of B12 Supplementation Appendix C