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This MAI cohort study showed that body composition changes differed by pre-pregnancy BMI and were linked with infant birth weight, especially among underweight and normal-weight women

The benefits in ASCVD risk reduction with GLP-1RA are evidenced by 14% risk reduction in cardiovascular mortality with an NNTB of 207 to prevent one event, 13% MACE reduction with an NNT of 67 to prevent one event and 12% risk reduction in stroke with an NNT of 335 to prevent one event, along with their favourable safety profile of 6% increased overall adverse events

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But if the deficiency is caused by an irreversible inability to absorb the vitamin, a lifelong treatment with pharmacological doses of B12 is needed

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