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Common reactions at typical doses include nausea, vomiting, diarrhea, constipation, and sometimes fatigue

Although the osteocyte is generally considered as the primary sensor of mechanical load, evidence of contributions by other cell populations are present in the literature

Patients should disclose all supplement use to their healthcare provider to avoid unwanted interactions

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Less common but more serious reported effects include pancreatitis, gallbladder disease, and potential thyroid C-cell tumours (observed in animal studies with semaglutide, though not confirmed in humans)

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