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Treatments with a family of lipid-lowering drugs known as fibrates (e.g., fenofibrate, bezofibrate) have been associated with an increased excretion of betaine in the urine and a rise in homocysteine concentration in the blood of patients with diabetes mellitus or metabolic syndrome (125, 126)

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In agreement, the QMP variant recombinantly expressed without the L585 residue (QMP/LX) (66.5 kDa) (Fig

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