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Because Accutane decreases sebum production, which can lead to dryness, the most common side effects include: Dry skin Dry mouth Chapped lips Nosebleeds (resulting from dry nasal passages) Dry eyes (especially in contact lens wearers) Other common side effects of Isotretinoin use include joint pain, muscle pain or aches, temporary hair thinning, skin irritation, and headaches

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This study highlighted the physiological importance of altering the signaling strength of these pathways as exon 3-deleted GHR individuals were found to be of higher stature with extended lifespan (113)