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Kozakova M, Palombo C, Paterni M, Dekker J, Flyvbjerg A, Mitrakou A, Gastaldelli A, Ferrannini E

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In rabbit models, intra-articular injection of scAAV2 encoding interleukin-1 receptor antagonist (IL-1Ra) yielded sustained therapeutic protein expression in both inflamed and normal joints for at least two weeks, with minimal immune activation or joint pathology (178)

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