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ERAD safeguards pancreatic -cell identity and insulin secretion Pancreatic -cells are uniquely vulnerable to ER stress due to their high insulin biosynthetic demand

The needle dulls slightly with each puncture, the inside is no longer sterile after first use, and the risk of contaminating the vial rises every time

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Most patients describe the sensation as a quick pinch rather than sharp pain, and discomfort typically resolves within minutes after injection completion