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4 A higher dose of 5 mg daily is recommended for those at increased risk of neural tube defects, and is available on prescription

Final research-target dose 2.4 mg + 2.4 mg weekly Titration length ~16 weeks Trial duration 68 weeks (REDEFINE 1 / REDEFINE 2) Route Subcutaneous, once weekly Compound Delivery: 2.4 mg / 2.4 mg Maintenance Pre-blended vials simplify weekly administration to a single injection but lock the ratio at 1:1

The loading dose concept

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Practical Considerations for Clinicians When discussing the potential blood pressure effects of GLP-1 medications with patients, careful framing is essential

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