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A novel class of incretin-based therapies consisting of glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) and dual (GLP1/glucose-dependent insulinotropic polypeptide [GIP]) RAs acts by lowering blood sugar and inducing weight loss

(117), emphasizes that regardless of monotherapy or combination regimens, reductions in BMI, waist circumference, fat mass, and visceral fat mass are consistent across most studies, with combination therapies often showing a greater magnitude of change

If a patient stops taking these medications, health benefits might not last

Mol Cell Endocrinol (2015) 418 Pt 1:4254

the interruption group resumed GLP-1RA use some time after cessation, while the discontinuation group never resumed

doi:10.1016/S0140-6736(22)02033-5 347