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These meds are often less expensive than semaglutide, and a 2025 trial published in the New England Journal of Medicine that compared both medications found that tirzepatide was more effective for weight losshelping participants drop up to 25% of their body weight over the course of the 72-week study

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The ongoing TRIUMPH-OUTCOMES study will provide definitive evidence about these cardiovascular effects, potentially establishing retatrutide as a cardiovascular therapeutic in addition to its metabolic indications

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