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It is primarily responsible for: Producing red blood cells Ensuring a healthy metabolism Supporting your nervous system

In a Treg Cd226 conditional knockout model, female NOD mice also displayed decreased insulitis and diabetes incidence, supporting the notion that CD226 is involved in Treg stability (95)

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[1] The American Diabetes Association (ADA) primarily recommends B12 monitoring for patients on long-term metformin therapy rather than for those on GLP-1/GIP receptor agonists