weight loss programs with glp 1 GLP-1 Injections: Semaglutide and Tirzepatide Comparing GLP‑1 Drugs With Other

NICE Technology Appraisal TA1026: Tirzepatide for managing overweight and obesity

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Tirzepatide (sold as Mounjaro and Zepbound) is a potent GIP analog with agonist activity at GIP and GLP-1 receptors

Their conclusions similarly highlight the advantages of GLP-1RAs for weight and select metabolic/clinical phenotypes but explicitly note that the evidence chain for long-term follow-up, lean PCOS, and reproductive endpoints (ovulation, pregnancy, and live birth) remains weak

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Food and Drug Administration (2024)