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Furthermore, the initial phase of rapid weight loss often coincides with the period when side effects like nausea or fatigue might be most pronounced 31 , potentially hindering a person's ability to start or maintain consistent strength training and ensure adequate protein intakethe very strategies needed to protect muscle

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This approach has been favored for its advantages in reducing the number of analytes, increasing analyte concentration, and improving analyte stability

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Our analysis of desensitization rates for the various mutants showed that although the mean weighted tau values slowed down when compared to wild type, they were not statistically significant (Fig