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Stimulating effects of H 2 S on glycolytic metabolism in cancer cells have been demonstrated to result from per-sulphidation of lactate dehydrogenase (LDH, particularly the LDH-A isoform) 149,150 and glyceraldehyde-3-phosphate dehydrogenase, although the functional consequences of per-sulphidation of the latter appear to be controversial

List Of Sources Used In This Article American Heart Association Journals

The biology behind it is not fully settled, but dose-response curves that peak and then fall off are common for signaling molecules, where too much of a stimulus can desensitize or overshoot the system it is meant to nudge

Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma

They are also the site of ROS production, especially when the cell is under stress