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GLP-1 receptor stimulation could promote satiety or avoidance of aversive drug effects through habenula-dependent mechanisms [53]

Master these, and you'll preserve muscle, minimize side effects, and achieve sustainable weight loss

In practice, they slow digestion, reduce hunger, and improve overall metabolic health, leading to better blood-sugar control, easier weight loss, and a lower risk of diabetes and heart disease

Evidence-based weight management includes intensive lifestyle modification with dietary counseling and physical activity, FDA-approved medications (prescription GLP-1 agonists, phentermine-topiramate, naltrexone-bupropion, orlistat), behavioral therapy, and metabolic/bariatric surgery for eligible patients

Prioritize colorful vegetables, berries, legumes, nuts, seeds, and whole grains when your appetite allows

During weeks 12-24, participants lost approximately 1.7 lbs per week on average at the higher doses