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Further information on safety reporting requirements in clinical trials is available via MHRA guidance on clinical trial safety reporting

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Subgroup analysis of the AOM cohort showed that tirzepatide users had a slightly lower incidence of obstructive sleep apnea than semaglutide users (2.65% vs 3.18%) (p=.0303)

third, impact on facial bone structuredecreased bone density and gradual bone resorption lead to a lack of effective bone support, causing facial skin to sag