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Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics

The GIP pathway adds something different

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Front Endocrinol (Lausanne) 2023;14:1050049

Amino acids are important because they either feed the production of insulin and Tg or are the substrate for the expression of enzymes, for example, glutamic acid for glutamic acid decarboxylase and tyrosine for thyroid peroxidase

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