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In addition, studies have found that compared with placebo, semaglutide significantly reduced AF incidence by 42% in high-cardiovascular-risk populations, and this effect was independent of administration route (oral/subcutaneous/injection), presence of underlying diabetes, and BMI (125, 127)

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8 Discussion and prospects In recent years, with the rapid advancement of technologies such as metabolomics and single-cell sequencing, research on COPD has shifted beyond traditional focus on three classic mechanismschronic inflammation, oxidative stress, and protease-antiprotease imbalance

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For example, in the STEP 8 trial, semaglutide 2.4 mg resulted in higher mean weight loss versus liraglutide 3.0 mg [27]

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