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5.7 Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, when used in combination with insulin

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By optimal utilization of ICS and LABA therapy to prevent asthma exacerbations, the study suggests that using budesonide-formoterol combination as a reliever therapy may be more efficacious than conventional combination or salbutamol or terbutaline monotherapy