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During the mean observation period of 3.3 years, semaglutide at 2.4 mg per week resulted in a mean weight loss of 9.39% from baseline and a 20% reduction in the risk of MACE (HR 0.80, 95% CI 0.720.90), especially a 28% reduction in the risk of myocardial infarction (HR 0.72, 95% CI 0.610.85), compared with that in the placebo group

6, we also employ the pooling layer to reduce the spatial dimensions of the input volume

Significance of the research This study clarifies the controversy regarding the effect of GLP-1 receptor agonists on body composition as a weight-management medication, and showcases how a genetic approach can enhance our understanding of how medications work