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[71] reported that elevated ferritin levelsnot low levelsare associated with increased overall mortality and cardiovascular deaths, challenging the conventional link between ferritin concentration and iron availability in heart failure patients

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While the largest percentage of intracellular iron is tightly bound to or incorporated into proteins as a cofactor or for storage, small portion of intracellular iron resides in the cytosol and intracellular organelles (e.g., lysosomes) and constitutes a redox-active liable iron pool, which regulates programmed cell death including ferroptosis 42

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Indeed, over-expression of arrestin 2 induces a selective uncoupling of DOR and KOR and reduces inhibition of ACase (Cheng et al., 1998)

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