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superoxide anion (O2), singlet oxygen radical (1O2), peroxyl radical (ROO), nitric oxide radical (NO) and lipid peroxy radical (LOO) as well as peroxynitrate (ONOO), trichloromethane (CHCl3) and hypochlorous acid (HOCl) which are not necessarily free radicals but have high tendency to generate free radicals
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They are often prescribed if: Metformin is not effective or tolerated Your A1C is still high despite other medications You are at risk for heart failure, kidney disease, or atherosclerosis These medications are used with diet, exercise, and other diabetes treatments
Clinically, I use a product called Methyl Power, which has clinical doses of each of these nutrients and will lower homocysteine levels when the issue has to do with B vitamin deficiencies
Patients buy brightening serums, get a single IPL session, or apply a prescription cream for a few months, see improvement, then watch the pigmentation return
References [1] Yang B, Liu Y, Li Y, et al
