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In the second trial, SURPASS-2, tirzepatide administered at doses of 5 mg, 10 mg, or 15 mg showed superior efficacy compared to semaglutide (1 mg) in reducing body weight and HbA1c levels over 40 weeks in patients with T2DM inadequately controlled with metformin [66]

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Plant Physiol Biochem 116:139149

PMID 29663628

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling