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The dark color of the intestinal lining may be uniform or patterned, and the discoloration may be slight or very pronounced

Current evidence also suggests no receptor desensitization or feedback suppression commonly discussed with long-term secretagogue use

All healthcare providers prescribing opioids need additional education and training to provide the best patient outcomes and navigate the social and legal issues associated with under and over-prescribing opioids

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[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Aboulmagd Y.M., El-Bahy A.A.Z., Menze E.T., Azab S.S., El-Demerdash E