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Cochrane Handbook for Systematic Reviews of Interventions version 6.5 (updated August 2024)

Glycemic and Anthropometric Secondary Outcomes Participants in the 6 mg group demonstrated a 2.4 mmol/mol reduction in HbA1c compared with a 0.1 mmol/mol reduction in the placebo group (p = 0.006)

A B12 deficiency disrupts your metabolism which has a knock-on effect on weight, appetite and energy levels

While its not a common side effect, some people feel tired temporarily as their bodies adjust

I was using the Axis-Y Dark Spot Correcting serum just prior to this, and that was a flop so my skin was primed to receive all the benefits of Vitamin C that I knew it loved