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Implications for stepped-care personalization Several phenotyping frameworks now assist clinical decision-making by enabling clinicians to customise treatment according to each patients biological profile

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Hormone replacement requires ongoing monitoring, can affect fertility, and produces systemic effects beyond sexual function

References Couzin-Frankel J 2023 Breakthrough of the Year

An older study from 2001 looked at the potential weight impacts of metformin in people with diabetes and morbid obesity (which this study identified as a body mass index, BMI, of 30 and above)