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Stemmer K, Finan B, DiMarchi RD, et al

Post-meal pharmacodynamic profile of AVE0010, a once-daily GLP-1 receptor agonist, in patients with type 2 diabetes inadequately controlled on metformin [abstract 131]

This is why the strict fasting requirement exists: taking Rybelsus on an empty stomach, with only a small amount of plain water (up to 120ml), and waiting at least 30 minutes before consuming anything else maximises the amount of active drug that enters the bloodstream

Yes-Zepbound and Mounjaro contain the same active ingredient (tirzepatide) but are FDA approved for different conditions: Zepbound for weight management and Mounjaro for type 2 diabetes

Its intestinal metabolites also exert beneficial functions

McCarty, D., Coleman, M