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Yet, challenges persist in balancing specificity and off-target effects, as evidenced by hepatic sequestration of folate-conjugated nanoparticles due to nonspecific uptake by Kupffer cells, sinusoidal endothelial cells, and hepatocytes, which remains a major hurdle for systemic delivery [154]
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These results indicate alterations in the digestive and absorption function of the intestine in mice with diarrhea with kidney-yang deficiency syndrome
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