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10.1056/NEJMe2202547 N Engl J Med

Shear stress-induced cellular senescence blunts liver regeneration through Notch-sirtuin 1-P21/P16 axis

Two functionally distinct subsites make up the active site of the enzyme (one on each monomer): a GSH-binding site (G-site) and a hydrophobic electrophile-binding site (H-site)

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Ethical approval The authors confirm that they have read the Journals position on issues involved in ethical publication and affirm that this report is consistent with those guidelines