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Common signs that a dose may be too high or increased too quickly include: Persistent nausea that does not improve with time

Ability to Work with Medical Experts Success in pharmaceutical litigation depends heavily on expert witness testimony establishing that the drug caused the plaintiffs injuries and that the manufacturer knew or should have known about these risks, requiring attorneys skilled at identifying, retaining, and preparing qualified medical experts

Although generally safe, injections should be used with caution in people with a history of allergic reactions to cobalamin or in people with Leber's disease (hereditary optic neuropathy), as B12 may worsen the condition

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In 1902, Bayliss and Starling made the first discovery of a hormone capable of stimulating pancreatic secretion, glucagon (Bayliss and Starling, 1902) (Figure 1B)