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For most people taking B12 at standard supplemental doses as part of a well-formulated multivitamin, this isn't a concern

Clinical trials have shown their efficacy and safety over several years, yet the possibility of long-term adverse effects remains a research focus

So, in general vitamin B12 IV therapy would be the most beneficial for: People with vitamin B12 deficiency and related anemia

Pinch the skin, insert the needle at a 45 to 90 degree angle (depending on body composition), inject slowly, hold for 5 to 10 seconds, withdraw

This allows assessment of tolerance before increasing to standard therapeutic doses of 1-2mg daily

A provider decides what belongs in any given plan