Adult mouse CMs (AMCMs) isolation Primary CMs were isolated according to a previously published protocol 48
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When examining the individual components of the primary endpoint, we observed closely concordant results for myocardial infarction and stroke but divergent results for all-cause mortality, suggestive of residual confounding
A pre-specified interim safety analysis conducted after the first 69 patients completed the study suggested no indication of increased risk of intracranial hemorrhage, malignant brain edema, neurological deterioration (as measured by changes in NIHSS from baseline to day 3), or poor neurological recovery (mRS 46 at 90 days) with semaglutide therapy (Table S4)
Blood glucose monitoring : Although hypoglycaemia is uncommon with Ozempic monotherapy, it can occur when combined with insulin or sulphonylureas